If you are struggling with symptoms of depression, you are not alone. SPRAVATO offers renewed hope for relief for individuals who have not had success with traditional treatment methods. This innovative medication delivers fast and lasting results, making it an empowering way to take control of your mental health and achieve long-awaited wellness.
Patients interested in this advanced treatment may have questions about the safety, efficacy, and FDA approval of SPRAVATO. At Upswing Psychiatry, our dedicated team is here to help you understand what to expect from SPRAVATO treatments so that you can make informed, confident decisions about your mental health.
SPRAVATO is an FDA-approved, advanced treatment for those with major depressive disorder who have not found relief from other treatments, such as antidepressants. It is administered in our office as a nasal spray and contains esketamine, which works differently from antidepressants. This compound acts on glutamate receptors in the brain that play a significant role in mood regulation. SPRAVATO also has the potential to impact neuroplasticity, the brain’s ability to heal and repair connections damaged by chronic depression.
SPRAVATO is clinically proven to treat depressive symptoms. Studies show that about 70 percent of patients who use SPRAVATO experience a significant reduction in depressive symptoms. In another study, 88 percent of patients reported complete resolution of symptoms after three months of in-office SPRAVATO treatments. This medication not only offers fast-acting improvement but also long-lasting results, as many patients continue to see improvement for two years or more with ongoing care.
SPRAVATO was approved by the FDA in 2019 for use in patients with treatment-resistant depression. This refers to patients who have tried two or more antidepressants without success. At the time of approval, eskatamine was approved for use in conjunction with an antidepressant.
The FDA approval was expanded in January 2025 to clear SPRAVATO as a monotherapy. This means esketamine is now approved as a standalone treatment for depression, and patients who use this nasal spray do not have to be on an oral medication as well. This marked a transformative milestone for our patients struggling with depression, as many cannot tolerate the unwanted side effects of antidepressant medication.
SPRAVATO’s FDA approval means this advanced therapy has undergone extensive testing by a highly accredited organization to determine its safety and efficacy. Like with any medical treatment, it is not right for everyone. Our compassionate providers will determine whether esketamine nasal spray could be safe for you during your initial consultation at our office. Here, we will ask you questions about your medical history, current mental health needs, and goals for treatment. Patients with certain uncontrolled medical conditions, such as high blood pressure, may not be good candidates for this treatment. Side effects of SPRAVATO can include:
Your safety and comfort are our top priorities in your mental health journey. During your SPRAVATO treatments, you will be connected to devices that continuously check your vital signs, and one of our team members will closely monitor your mental and physical wellness.
SPRAVATO is an advanced treatment for those still searching for emotional balance after not having had success with traditional antidepressants. Our expert team of board-certified psychiatry providers is here to guide you toward wellness through evidence-based treatments that meet your unique needs. SPRAVATO is a highly studied nasal spray that offers transformative results for our patients. Contact us today to schedule an initial consultation and learn more about the FDA approval of SPRAVATO.